If your arrival point is Madrid, you'll need to work out how to get to Barcelona. With the new AVE train route from Madrid to Barcelona, you can get between Spain's two biggest cities quicker than ever - just two-and-a-half hours. You can book the train here: Rail Tickets in Europe. It's quick, but also quite expensive. Read more on the various Madrid to Barcelona transport options.
If you want a guided tour that takes you from Madrid to Barcelona, check out the options on this page. There is a day trip to Barcelona, a tour that just covers Spain's eastern cities, some that cover Andalusia too and some mammoth tours that cover the whole country.
See also: 100 Things to Do in Madrid
1. Barcelona Day Trip from Madrid
Before the AVE train route from Madrid to Barcelona came into service a few years back, this day trip wasn't even possible. Now you can jump on the train in the morning, have a full day in Barcelona and be back in your own bed in the evening.
This tour includes all transport, a guided tour of Barcelona and some free time in the city.
More on this tour: Day Trip from Madrid to Barcelona
2. Four-Day Tour of Barcelona and Valencia from Madrid
Visit Spain's no.2 and no.3 cities (by population) from its number 1. This tour takes you from Madrid to Valencia, for a night at the birthplace of paella, before driving up to Barcelona, where you spend two nights. Then it's back to Madrid via a short stop in Zaragoza.
More on this tour: Four-Day Trip from Madrid: Barcelona and Valencia (and Zaragoza)
3. Five-Day Tour of Catalonia from Madrid
This is a tour more for people who have been to Barcelona before but have unfinished business in the wider region of Catalonia. This guided tour has a night in Barcelona at the beginning of the tour and leaves you there at the end of the tour, but the days in between are spent exploring the rest of Catalonia.
Further details: Catalonia Tour from Madrid
4. Seven-Day Tour of Andalusia, Barcelona and Valencia from Madrid
See the three highlights of Andalusia - the Alhambra in Granada, the mosque/cathedral in Cordoba and the city of Seville (where you will spend two nights) before going on to visit Valencia, Barcelona (two nights) and Zaragoza.
At under 100 euros per day, including three-star accommodation, transport, guided tours and some meals, this really is an amazingly good value way of seeing the biggest sights in Spain in a single week. But if you have a little extra time, you might want to consider the tours below, which include everything in this tour and more.
5. Nine-Day Tour of Andalusia, Barcelona and Valencia from Madrid
As the above seven-day tour, but adding in Caceres and Ronda and a night on the Costa del Sol.
6. Twelve-Day Tour of Portugal, Andalusia, Barcelona and Valencia
As the above nine-day tour, but with Trujillo in Spain and Lisbon and Fatima in Portugal added to the start of the tour.
More on this tour: Twelve-Day Tour of Portugal, Andalusia, Barcelona and Valencia
7. Nineteen-Day Tour of Spain and Portugal (including Barcelona)
As the above 12-day tour, but after Barcelona the tour heads up to San Sebastian and Bilbao, before heading along the coast into 'Green Spain'.
The north of Spain couldn't be more different from Andalusia, and you can't really say you know Spain until you've been up there.
More on this tour: Extended Tour of Spain and Portugal (including Barcelona)